J Popul Ther Clin Pharmacol. 2019 Jul 26;26(2):e20-e24. doi: 10.15586/jptcp.v26i2.624.


Ochronotic degenerative arthropathy occurs in patients with alkaptonuria. Alkaptonuria disorder is an extremely rare disease characterized by black pigmentation of various tissues (e.g., cartilage and connective tissue). Ochronotic arthropathy is a disabling disease that primarily affects the large joints. Like other metabolic diseases that involve the musculoskeletal system, care must be taken with regard to the quality of the affected bones, tendons and ligaments, and therefore the stability and survival of joint prosthesis. The following is a report of a 66-year-old man affected by several musculoskeletal manifestations of alkaptonuria with severe joints disruption, who was successfully treated with total left hip and total right knee replacements. Surgical, anesthesiological and postoperative management of these patients may require more vigilance due to the associated comorbidities of this disorder.

Keywords: alkaptonuria; ochronotic arthopathy; total hip arthroplasty; total knee arthroplasty.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Alkaptonuria / physiopathology
  • Alkaptonuria / surgery*
  • Arthroplasty, Replacement, Hip / methods*
  • Arthroplasty, Replacement, Knee / methods*
  • Humans
  • Male
  • Ochronosis / physiopathology
  • Ochronosis / surgery*
  • Treatment Outcome

Supplementary concepts

  • Alkaptonuric ochronosis