L-5-hydroxytryptophan in the treatment of anxiety disorders

J Affect Disord. Mar-Apr 1985;8(2):197-200. doi: 10.1016/0165-0327(85)90046-1.


Ten outpatients suffering from anxiety states (Anxiety Disorders: DSM-III) were treated with L-5-hydroxytryptophan and carbidopa. A significant reduction in anxiety was observed on three different anxiety scales. It is suggested that 5-HT systems may be involved in the mediation of anxiety.

MeSH terms

  • 5-Hydroxytryptophan / therapeutic use*
  • Anxiety Disorders / drug therapy*
  • Carbidopa / therapeutic use
  • Drug Therapy, Combination
  • Female
  • Humans
  • Male
  • Receptors, Serotonin / physiology


  • Receptors, Serotonin
  • 5-Hydroxytryptophan
  • Carbidopa