Comparison of 'post-patent ductus arteriosus ligation syndrome' in premature infants after surgical ligation vs. percutaneous closure

Ryan M Serrano; Mackenzie Madison; Diane Lorant; Mark Hoyer; Ryan Alexy

doi:10.1038/s41372-019-0513-8

Comparison of 'post-patent ductus arteriosus ligation syndrome' in premature infants after surgical ligation vs. percutaneous closure

J Perinatol. 2020 Feb;40(2):324-329. doi: 10.1038/s41372-019-0513-8. Epub 2019 Oct 2.

Authors

Ryan M Serrano¹, Mackenzie Madison¹, Diane Lorant², Mark Hoyer¹, Ryan Alexy^{3

4}

Affiliations

¹ Riley Hospital for Children, Department of Pediatric Cardiology, Indianapolis, IN, USA.
² Riley Hospital for Children, Department of Neonatology, Indianapolis, IN, USA.
³ Riley Hospital for Children, Department of Pediatric Cardiology, Indianapolis, IN, USA. ralexy@iu.edu.
⁴ Riley Hospital for Children, Department of Neonatology, Indianapolis, IN, USA. ralexy@iu.edu.

PMID: 31578421
DOI: 10.1038/s41372-019-0513-8

Abstract

Objective: To compare the incidence of post-PDA ligation syndrome after surgical vs. percutaneous closure of PDAs in very low birth weight (VLBW) infants.

Study design: Cohort study comparing 59 infants who underwent surgical ligation with 25 infants who underwent percutaneous closure. Comparisons between groups were made using two-sample t-tests and a Fisher's exact test. Comparisons of pre vs. post variables within each group were made using paired t-tests.

Results: Patients who underwent surgical ligation had a higher need for initiation of post-procedure hemodynamic support (12/59 vs. 0/24, p = 0.016), a higher post-procedure peak FiO₂ (0.64 vs. 0.43, p = 0.004), and a larger absolute change in peak FiO₂ (0.23 vs. 0.09, p = 0.008).

Conclusion: VLBW infants who had percutaneous closure of their PDA did not experience post ligation syndrome and had less escalation of respiratory support compared with infants who underwent surgical ligation.

Publication types

Comparative Study

MeSH terms

Cardiac Catheterization / adverse effects*
Cohort Studies
Ductus Arteriosus, Patent / surgery*
Ductus Arteriosus, Patent / therapy
Humans
Infant, Newborn
Infant, Premature*
Infant, Premature, Diseases / surgery*
Infant, Premature, Diseases / therapy
Infant, Very Low Birth Weight*
Ligation / adverse effects*