Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 11 (3), 8268

Influenza Virus B-associated Hemophagocytic Lymphohistiocytosis


Influenza Virus B-associated Hemophagocytic Lymphohistiocytosis

Jackson Gao et al. Hematol Rep.


This original report describes the diagnosis and management of a male with hemophagocytic lymphohistiocytosis (HLH) triggered by influenza B virus infection. The patient was diagnosed with HLH- 2004 clinical criteria and a bone marrow biopsy demonstrating hemophagocytes. Therapy consisted of etoposide and dexamethasone while monitoring hemoglobin and platelet levels. To enable early recognition and prompt treatment for this disease, physicians should be aware of this association.

Keywords: Hemophagocytic Lymphohistiocytosis; Influenza B virus; hemophagocyte.

Conflict of interest statement

Conflict of interest: the authors declare no potential conflict of interest.


Figure 1.
Figure 1.
Bone marrow aspirate showing phagocytosis of neutrophils, erythrocytes, and platelets by hemophagocyte (black arrow). H&E stain.

Similar articles

See all similar articles


    1. Emile JF, Abla O, Fraitag S, et al. Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood 2016;127: 2672-81. - PMC - PubMed
    1. McClain K, Gehrz R, Grierson H, et al. Virus-associated histiocytic proliferations in children. Frequent association with Epstein-Barr virus and congenital or acquired immunodeficiencies. Am J Pediatr Hematol Oncol 1988;10:196. - PubMed
    1. Rouphael NG, Talati NJ, Vaughan C, et al. Infections associated with haemophagocytic syndrome. Lancet Infect Dis 2007;7:814-22. - PubMed
    1. Harms PW, Schmidt LA, Smith LB, et al. Autopsy findings in eight patients with fatal H1N1 influenza. Am J Clin Pathol 2010;134:27. - PubMed
    1. Chen TL, Wong WW, Chiou TJ. Hemophagocytic syndrome: an unusual manifestation of acute human immunodeficiency virus infection. Int J Hematol 2003;78:450. - PubMed

Grant support

Funding: none.