Fifty Shades of α-Ketoglutarate on Cellular Programming

Giusy Di Conza; Chin-Hsien Tsai; Ping-Chih Ho

doi:10.1016/j.molcel.2019.09.002

Fifty Shades of α-Ketoglutarate on Cellular Programming

Mol Cell. 2019 Oct 3;76(1):1-3. doi: 10.1016/j.molcel.2019.09.002.

Authors

Giusy Di Conza¹, Chin-Hsien Tsai¹, Ping-Chih Ho²

Affiliations

¹ Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland; Ludwig Institute for Cancer Research, University of Lausanne, Épalinges, Switzerland.
² Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland; Ludwig Institute for Cancer Research, University of Lausanne, Épalinges, Switzerland. Electronic address: ping-chih.ho@unil.ch.

PMID: 31585100
DOI: 10.1016/j.molcel.2019.09.002

Abstract

High plasticity to utilize different nutrients to adapt metabolic stress is one of the hallmarks for cancer cells. However, the underlying mechanisms by which cancer cells reprogram metabolic machinery in response to metabolic stress remain largely unclear. In this issue of Molecular Cell, Wang et al. (2019) report that glutamate dehydrogenase 1 (GDH1) induces an unconventional regulation of the NF-κB pathway under glucose deprivation, thereby stimulating glycolysis in glioblastomas.

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MeSH terms

Brain Neoplasms*
Glucose
Glycolysis
Humans
Ketoglutaric Acids
NF-kappa B*

Substances

Ketoglutaric Acids
NF-kappa B
Glucose