Rare basal cell metastasis of a basal-squamous skin collision tumour to the lung and axillary lymph node

BMJ Case Rep. 2019 Oct 3;12(10):e231487. doi: 10.1136/bcr-2019-231487.

Abstract

We report a case of a 60-year-old man who was a former cigar smoker with a slow-growing, large exophytic left shoulder mass (15 cm in diameter) and later found to have left axillary lymphadenopathy. Fine needle aspirate biopsy of the left shoulder mass revealed squamous cell carcinoma (SCC). However, pathology of the enlarged left axillary lymph node was reported as metastatic adenocarcinoma. The patient underwent surgical resection of the shoulder mass which comprised of SCC (>95%) and adenoid basal cell carcinoma (BCC) as a second component of the tumour. The BCC had identical histology as the metastatic carcinoma in the left axillary lymph node. Therefore, diagnosis was revised as cutaneous collision tumour with metastatic BCC. Six months later following adjuvant radiation therapy, the patient was diagnosed with metastatic BCC in the right lung. Stereotactic body radiation therapy (SBRT) and a selective hedgehog pathway inhibitor vismodegib were given with only limited efficacy. Clinical trial registration number NCT03132636.

Keywords: lung cancer (oncology); skin cancer.

Publication types

  • Case Reports

MeSH terms

  • Anilides / administration & dosage
  • Anilides / therapeutic use
  • Axilla / pathology
  • Carcinoma, Basal Cell / pathology
  • Carcinoma, Basal Cell / radiotherapy
  • Carcinoma, Basal Cell / secondary*
  • Carcinoma, Squamous Cell / complications
  • Carcinoma, Squamous Cell / pathology*
  • Carcinoma, Squamous Cell / surgery
  • Hedgehog Proteins / antagonists & inhibitors
  • Humans
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / pathology
  • Lung Neoplasms / radiotherapy
  • Lung Neoplasms / secondary*
  • Lymph Nodes / pathology*
  • Lymph Nodes / surgery
  • Male
  • Middle Aged
  • Pyridines / administration & dosage
  • Pyridines / therapeutic use
  • Radiosurgery / methods
  • Radiotherapy, Adjuvant / methods
  • Skin Neoplasms / pathology
  • Skin Neoplasms / surgery*
  • Treatment Outcome

Substances

  • Anilides
  • Hedgehog Proteins
  • HhAntag691
  • Pyridines

Associated data

  • ClinicalTrials.gov/NCT03132636