Involvement of l-lactate in hippocampal dysfunction of type I diabetes

J Pharmacol Sci. 2019 Sep;141(1):79-82. doi: 10.1016/j.jphs.2019.09.004. Epub 2019 Sep 13.


Hippocampal neurons play a crucial role in memory formation. Accumulating evidence raises the possibility that hippocampal sharp-wave ripples (SW-Rs) are involved in memory consolidation. Here, we examined in an animal model of diabetes and found the amplitude of SW-Rs in diabetic mice were smaller than control group and were rescued by acute application of l-lactate, a major neural energy source. The cognitive impairment in diabetic mice was alleviated by intracerebroventricular l-lactate treatment. Our results suggested that l-lactate is important for hippocampal dysfunction in diabetes.

Keywords: Cognitive impairment; Diabetes mellitus; Sharp wave ripples (SW-Rs).

MeSH terms

  • Animals
  • Cognitive Dysfunction / drug therapy*
  • Cognitive Dysfunction / etiology
  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 1 / psychology*
  • Disease Models, Animal
  • Hippocampus / physiopathology*
  • Injections, Intraventricular
  • Lactates / administration & dosage*
  • Lactates / pharmacology
  • Male
  • Memory / physiology*
  • Mice
  • Mice, Inbred ICR
  • Neurons / physiology*


  • Lactates