Neural bases of impulse control disorders in Parkinson's disease: A systematic review and an ALE meta-analysis

Neurosci Biobehav Rev. 2019 Dec;107:672-685. doi: 10.1016/j.neubiorev.2019.09.041. Epub 2019 Oct 3.

Abstract

Impulse control disorders (ICD) occur in some patients affected by Parkinson's disease (PD). Previous studies revealed an involvement of basal ganglia in ICD, but recent morphological, molecular and functional imaging studies showed that alterations of some extrastriatal regions contribute to development of ICD in PD, with mixed results. To identify the brain regions underlying ICD in PD, a systematic review of morphometric and functional studies was performed, complemented by an ALE meta-analysis of functional studies. The review of structural studies revealed no significant changes in any cortical and subcortical region in patients with ICD. The review of functional studies revealed increased activity in the Ventral Striatum and OrbitoFrontal Cortex and decreased activity in Anterior Cingulate Cortex (ACC). Clusters of hyperactivation in ventral striatum and of hypoactivation in ACC were confirmed by ALE meta-analysis. In conclusion, the present study strongly supported that ICD in PD are related to a dysfunction of limbic divisions of the striatum and of the prefrontal cortex and provided a neurofunctional basis for devising potential therapeutic interventions.

Keywords: Impulse control disorders; Neural correlates; Parkinson’s disease; Prefrontal cortex; Striatum.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Brain / diagnostic imaging
  • Brain / physiopathology*
  • Disruptive, Impulse Control, and Conduct Disorders / diagnostic imaging
  • Disruptive, Impulse Control, and Conduct Disorders / etiology*
  • Disruptive, Impulse Control, and Conduct Disorders / physiopathology
  • Functional Neuroimaging
  • Humans
  • Parkinson Disease / complications*
  • Parkinson Disease / diagnostic imaging
  • Parkinson Disease / physiopathology
  • Parkinson Disease / psychology