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. 2019 Dec;15(12):1603-1611.
doi: 10.1016/j.jalz.2019.07.013. Epub 2019 Oct 3.

Current and Past Leisure Time Physical Activity in Relation to Risk of Alzheimer's Disease in Older Adults

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Free PMC article

Current and Past Leisure Time Physical Activity in Relation to Risk of Alzheimer's Disease in Older Adults

Erika Ogino et al. Alzheimers Dement. .
Free PMC article

Abstract

Introduction: The associations between self-reported current and past leisure time physical activity (LTPA) and Alzheimer's disease (AD) incidence were determined using data from the multiethnic Washington/Hamilton Heights-Inwood Columbia Aging Project (WHICAP) study.

Methods: The metabolic equivalent of LTPA energy expenditure was calculated for self-reported current and past LTPA for 1345 older adults. A Cox proportional hazard model was conducted to estimate the association between LTPA (low, middle, and high) and incident AD risk.

Results: Comparing high to low level, current and past LTPA were both associated with reduced AD risk, with hazard ratio (95% confidence interval) = 0.39 (0.20-0.75) and 0.37 (0.18-0.75), respectively. Compared with "always low," "increased" and "always high" LTPA throughout life were associated with reduced AD risk, with hazard ratio (95% confidence interval) = 0.60 (0.36-0.99) and 0.28 (0.08-0.94), respectively. Light- and moderate-intensity LTPA were associated with lower AD risk.

Discussion: LTPA both throughout life and later in life are associated with lower risk of AD.

Keywords: Alzheimer's disease; Dementia; Epidemiology; Longitudinal study; Physical activity.

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