Update on Antithrombotic Therapy after Percutaneous Coronary Intervention

Intern Med. 2020 Feb 1;59(3):311-321. doi: 10.2169/internalmedicine.3685-19. Epub 2019 Oct 7.


Percutaneous coronary intervention (PCI) has become a standard-of-care procedure in the setting of angina or acute coronary syndrome. Antithrombotic therapy is the cornerstone of pharmacological treatment aimed at preventing ischemic events following PCI. Dual antiplatelet therapy as the combination of aspirin and P2Y12 inhibitor has been proven to decrease stent-related thrombotic risks. However, the optimal duration of dual antiplatelet therapy, an appropriate P2Y12 inhibitor, and the choice of aspirin versus P2Y12 inhibitor as single antiplatelet therapy remain controversial. Furthermore, the combined use of oral anticoagulation in addition to antiplatelet therapy is a complex issue in clinical practice, such as in patients with atrial fibrillation. The key challenge concerning the optimal antithrombotic regimen is ensuring a balance between protection against thrombotic events and against excessive increases in bleeding risk. In this review article, we summarize the current evidence concerning antithrombotic therapy in patients with coronary artery disease undergoing PCI.

Keywords: antithrombotic therapy; dual antiplatelet therapy; percutaneous coronary intervention.

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Anticoagulants / therapeutic use*
  • Aspirin / therapeutic use*
  • Coronary Artery Disease / therapy*
  • Drug Therapy, Combination
  • Humans
  • Ischemia / drug therapy*
  • Ischemia / etiology*
  • Percutaneous Coronary Intervention / adverse effects*
  • Purinergic P2Y Receptor Agonists / therapeutic use*


  • Anticoagulants
  • Purinergic P2Y Receptor Agonists
  • Aspirin