Impact of DARC, GSDMA and CXCL2 polymorphisms on induction toxicity in children with acute lymphoblastic leukemia: A complementary study

Leuk Res. 2019 Nov:86:106228. doi: 10.1016/j.leukres.2019.106228. Epub 2019 Sep 29.

Authors

S Gatineau-Sailliant¹, S Glisovic², V Gagné², C Laverdière³, J M Leclerc³, L B Silverman⁴, D Sinnett³, M Krajinovic⁵, Y Pastore³

Affiliations

¹ Department of Pediatrics, Faculty of Medicine, University of Montreal, Qc, Canada.
² Charles Bruneau Center, CHU Sainte-Justine Research Center, Montreal, Canada.
³ Department of Pediatrics, Faculty of Medicine, University of Montreal, Qc, Canada; Charles Bruneau Center, CHU Sainte-Justine Research Center, Montreal, Canada.
⁴ Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Division of Hematology/Oncology, Children's Hospital, Boston, USA.
⁵ Department of Pediatrics, Faculty of Medicine, University of Montreal, Qc, Canada; Charles Bruneau Center, CHU Sainte-Justine Research Center, Montreal, Canada; Department of Pharmacology and Physiology, University of Montreal, Canada. Electronic address: Maja.krajinovic@umontreal.ca.

PMID: 31590117
DOI: 10.1016/j.leukres.2019.106228

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / adverse effects*
Biomarkers, Tumor / genetics
Chemokine CXCL2 / genetics*
Child
Drug-Related Side Effects and Adverse Reactions / diagnosis*
Drug-Related Side Effects and Adverse Reactions / etiology
Duffy Blood-Group System / genetics*
Follow-Up Studies
Humans
Induction Chemotherapy / mortality
Neoplasm Proteins / genetics*
Polymorphism, Genetic*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology*
Prognosis
Receptors, Cell Surface / genetics*
Retrospective Studies
Survival Rate

Substances

ACKR1 protein, human
Biomarkers, Tumor
CXCL2 protein, human
Chemokine CXCL2
Duffy Blood-Group System
GSDMA protein, human
Neoplasm Proteins
Receptors, Cell Surface

Grants and funding

CIHR/Canada