Obesity is a significant contributor to increased morbidity and premature mortality due to increasing the risk of many chronic metabolic diseases such as type 2 diabetes, cardiovascular disease and certain types of cancer. Lifestyle modifications such as energy restriction and increased physical activity are highly effective first-line treatment strategies used in the management of obesity. However, adherence to these behavioral changes is poor, with an increased reliance on synthetic drugs, which unfortunately are plagued by adverse effects. The identification of new and safer anti-obesity agents is thus of significant interest. In recent years, plants and their phenolic constituents have attracted increased attention due to their health-promoting properties. Amongst these, Cyclopia, an endemic South African plant commonly consumed as a herbal tea (honeybush), has been shown to possess modulating properties against oxidative stress, hyperglycemia, and obesity. Likewise, several studies have reported that some of the major phenolic compounds present in Cyclopia spp. exhibit anti-obesity effects, particularly by targeting adipose tissue. These phenolic compounds belong to the xanthone, flavonoid and benzophenone classes. The aim of this review is to assess the potential of Cyclopia extracts as an anti-obesity nutraceutical as underpinned by in vitro and in vivo studies and the underlying cellular mechanisms and biological pathways regulated by their phenolic compounds.
Keywords: Adipose tissue; Cyclopia; Obesity; Phenolic compounds.
Copyright © 2019 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
The Potential Role of Polyphenols in the Modulation of Skin Cell Viability by Aspalathus Linearis and Cyclopia Spp. Herbal Tea Extracts in VitroTU Magcwebeba et al. J Pharm Pharmacol 68 (11), 1440-1453. PMID 27671741.The polyphenol constituents and antioxidant parameters of herbal tea extracts are useful tools to predict their activity against skin cell survival in vitro and potential …
Cyclopia Maculata and Cyclopia Subternata (Honeybush Tea) Inhibits Adipogenesis in 3T3-L1 Pre-AdipocytesZ Dudhia et al. Phytomedicine 20 (5), 401-8. PMID 23428403.The stems, leaves and flowers of Cyclopia have been consumed as a herbal tea 'honeybush tea' to treat various medical ailments since the 19th century. Plant polyphenols a …
Effect of Species Variation and Processing on Phenolic Composition and in Vitro Antioxidant Activity of Aqueous Extracts of Cyclopia Spp. (Honeybush Tea)E Joubert et al. J Agric Food Chem 56 (3), 954-63. PMID 18198832.The in vitro antioxidant activity of aqueous extracts prepared from four Cyclopia spp. (unfermented and fermented) was assessed using radical (ABTS *+) scavenging, ferric …
A Review of the Bioactivity of South African Herbal Teas: Rooibos (Aspalathus Linearis) and Honeybush (Cyclopia Intermedia)DL McKay et al. Phytother Res 21 (1), 1-16. PMID 16927447. - ReviewRooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia) are popular tisanes in their native South Africa and have a growing worldwide market. Both herbal teas a …
Honeybush (Cyclopia Sp.) - A Rich Source of Compounds With High Antimutagenic PropertiesA Kokotkiewicz et al. Fitoterapia 80 (1), 3-11. PMID 19032980. - ReviewThe genus Cyclopia (Fabaceae family) includes a number of shrubs endemic to Cape Fynbos region of South Africa. The most common of these plants is Cyclopia intermedia E. …