Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Oct 6;8(10):1635.
doi: 10.3390/jcm8101635.

Elevated Hedgehog-Interacting Protein Levels in Subjects With Prediabetes and Type 2 Diabetes

Affiliations
Free PMC article

Elevated Hedgehog-Interacting Protein Levels in Subjects With Prediabetes and Type 2 Diabetes

An-Chi Lin et al. J Clin Med. .
Free PMC article

Abstract

Background: The prevalence of diabetes is rapidly increasing worldwide and is highly associated with the incidence of cancers. In order to prevent diabetes, early diagnosis of prediabetes is important. However, biomarkers for prediabetes diagnosis are still scarce. The hedgehog-interacting protein (Hhip) is important in embryogenesis and is known to be a biomarker of several cancers. However, Hhip levels in subjects with diabetes are still unknown.

Methods: In total, 314 participants were enrolled and divided into normal glucose tolerance (NGT; n = 75), impaired fasting glucose (IFG; n = 66), impaired glucose tolerance (IGT; n = 86), and newly diagnosed diabetes (NDD; n = 87) groups. Plasma Hhip levels were determined by an ELISA. The association between the Hhip and the presence of diabetes was examined by a multivariate linear regression analysis.

Results: There were significant differences in the body mass index, systolic and diastolic blood pressure, fasting plasma glucose (FPG), post-load 2-h glucose, hemoglobin A1c (A1C), C-reactive protein, total cholesterol, triglyceride, and high- and low-density lipoprotein cholesterol levels among the groups. Concentrations of the Hhip were 2.45 ± 2.12, 4.40 ± 3.22, 4.44 ± 3.64, and 6.31 ± 5.35 ng/mL in subjects in the NGT, IFG, IGT, and NDD groups, respectively. In addition, we found that A1C and FPG were independently associated with Hhip concentrations. Using NGT as a reference group, IFG, IGT, and NDD were all independently associated with Hhip concentrations.

Conclusions: Hhip was positively associated with prediabetes and type 2 diabetes mellitus.

Keywords: hedgehog-interacting protein; impaired fasting glucose; impaired glucose tolerance; newly diagnosed diabetes; normal glucose tolerance.

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Plasma concentrations of the hedgehog-interacting protein (Hhip) in subjects with prediabetes or diabetes. Box and whisker plot of plasma Hhip concentrations in participants with normal glucose tolerance (NGT; n = 75), impaired fasting glucose (IFG; n = 66), impaired glucose tolerance (IGT; n = 86), and type 2 diabetes (T2D; n = 87). The line inside the box represents the median of the distribution, the box top and bottom values are defined by the 25th and 75th percentiles, and the whiskers are minimum and maximum values.

Similar articles

See all similar articles

References

    1. IDF Diabetes Atlas Eighth Edition 2017. [(accessed on 14 August 2019)]; Available online: http://www.diabetesatlas.org.
    1. Diabetes.co.uk Diabetes and Cancer. [(accessed on 14 August 2019)]; Available online: https://www.diabetes.co.uk/diabetes-complications/diabetes-and-cancer.html.
    1. American Diabetes Association 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2019. Diabetes Care. 2019;42:S13–S28. doi: 10.2337/dc19-S002. - DOI - PubMed
    1. Hsueh W.A., Orloski L., Wyne K. Prediabetes: The importance of early identification and intervention. Postgrad Med. 2010;122:129–143. doi: 10.3810/pgm.2010.07.2180. - DOI - PubMed
    1. Davidson M.B. Counterpoint: The oral glucose tolerance test is superfluous. Diabetes Care. 2002;25:1883–1885. doi: 10.2337/diacare.25.10.1883. - DOI - PubMed
Feedback