Frontal lobe syndromes

Handb Clin Neurol. 2019;163:147-164. doi: 10.1016/B978-0-12-804281-6.00008-2.


The frontal lobes contain a complex set of diverse anatomic regions that form multiple distinct, complex networks with cortical and subcortical regions. Damage to these cortical-subcortical networks can have dramatic behavioral consequences, ranging from apathy to impairments in executive functioning. This chapter provides a brief overview of the common syndromes caused by damage to the mediodorsal and dorsolateral prefrontal circuits, followed by a more detailed review of the syndrome-sometimes referred to as pseudopsychopathy or acquired sociopathy-associated with damage to the ventromedial prefrontal circuit.

Keywords: Abulia; Acquired sociopathy; Apathy; Dorsolateral; Orbitofrontal; Perseveration; Prefrontal; Pseudopsychopathy; Ventromedial.

Publication types

  • Review

MeSH terms

  • Agnosia / physiopathology*
  • Apathy / physiology
  • Emotions / physiology*
  • Executive Function / physiology*
  • Frontal Lobe / physiopathology*
  • Frontotemporal Dementia / physiopathology*
  • Humans
  • Motivation / physiology
  • Nerve Net / physiopathology*
  • Neuropsychological Tests