To explore the therapeutic effect of fecal microbiota transplantation (FMT) for severe psoriasis. A patient, male, 36 years old, diagnosed as severe plaque psoriasis for 10 years and irritable bowel syndrome (IBS) for 15 years, was administrated twice FMT via both upper endoscopy and colonoscopy with a 5-week interval. The following items were used to evaluate responses: body surface area (BSA), psoriasis area and severity index (PASI), dermatology life quality index (DLQI), histological examination, intestinal symptoms, adverse reactions and serum level of tumor necrosis factor (TNF)-α. After second FMT treatment for 5 weeks, aforementioned items were improved greatly compared with those before treatment. Moreover, IBS was completely relieved and no adverse reactions were observed during the treatment and follow-up. In conclusion, FMT could be a novel therapy for psoriasis. Further clinical trials are needed to provide solid evidences.
通过肠微生态移植重建（FMT）治疗重度银屑病，探索治疗银屑病的新方法。患者男，36岁，患寻常型银屑病10年，肠易激综合征15年，进行2次胃、肠镜联合FMT治疗。评估治疗前后皮损累及体表面积（BSA）、银屑病面积和严重程度指数（PASI）、生活质量指数（DLQI）、皮肤组织病理、肠道症状、安全性及血清肿瘤坏死因子α等。结果显示，FMT治疗该例银屑病患者临床疗效显著，肠易激综合征临床症状消失，且无不良反应发生。提示FMT可能是治疗银屑病的一种新疗法，值得进一步研究。.
Keywords: Fecal microbiota transplantation; Irritable bowel syndrome; Psoriasis.