House dust mite allergy and shrimp allergy: a complex interaction

Eur Ann Allergy Clin Immunol. 2020 Sep;52(5):205-209. doi: 10.23822/EurAnnACI.1764-1489.108. Epub 2020 Sep 7.


Background and Objective. Sensitization and allergy to shrimp among Italian house dust mite allergic patients are not well defined and were investigated in a large multicenter study. Methods. Shrimp sensitization and allergy were assessed in 526 house dust mite (HDM)-allergic patients submitted to the detection of IgE to Der p 10 and 100 atopic control not sensitized to HDM. Results. Shrimp allergy occurred in 9% of patients (vs 0% of 100 atopic controls not sensitized to HDM; p minor 0.001). Shrimp-allergic patients were less frequently hypersensitive to airborne allergens other than HDM than crustacean-tolerant subjects (35% vs 58.8%; p minor 0.005). Only 51% of tropomyosin-sensitized patients had shrimp allergy, and these showed significantly higher Der p 10 IgE levels than shrimp-tolerant ones (mean 22.2 KU/l vs 6.2 KU/l; p minor 0.05). Altogether 53% of shrimp-allergic patients did not react against tropomyosin. Conclusions. Shrimp allergy seems to occur uniquely in association with hypersensitivity to HDM allergens and tropomyosin is the main shrimp allergen but not a major one, at least in Italy. Along with tropomyosin-specific IgE levels, monosensitization to HDM seems to represent a risk factor for the development of shrimp allergy among HDM allergic patients.

Keywords: cross-reactivity; food allergy; house dust mite allergy; shrimp allergy.

MeSH terms

  • Adolescent
  • Adult
  • Animals
  • Antigens, Dermatophagoides / immunology*
  • Arthropod Proteins / immunology*
  • Cross Reactions
  • Female
  • Food Hypersensitivity / epidemiology*
  • Food Hypersensitivity / immunology
  • Humans
  • Immunoglobulin E / metabolism
  • Italy / epidemiology
  • Male
  • Middle Aged
  • Penaeidae
  • Prevalence
  • Pyroglyphidae
  • Tropomyosin / immunology*
  • Young Adult


  • Antigens, Dermatophagoides
  • Arthropod Proteins
  • Tropomyosin
  • Immunoglobulin E