Suppression of generation of concomitant antitumor immunity by passively transferred suppressor T cells from tumor-bearing donors

Cancer Immunol Immunother. 1985;19(3):215-8. doi: 10.1007/BF00199229.

Abstract

Infusion of normal recipient mice with suppressor T cells from donors bearing a progressive Meth A fibrosarcoma results in a diminished capacity of the recipients to generate concomitant and postexcision antitumor immunity. The passive transfer of suppressor cells which prevented the generation of immunity to the Meth A fibrosarcoma did not affect the capacity of the recipients to reject an allogeneic tumor. The data provides direct evidence in support of the hypothesis that suppressor T cells, generated at later stages of growth of Meth A fibrosarcoma, function to down-regulate an already acquired mechanism of concomitant immunity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Fibrosarcoma / chemically induced
  • Fibrosarcoma / immunology*
  • Immunization, Passive
  • Methylcholanthrene
  • Mice
  • Mice, Inbred A
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Neoplasm Transplantation
  • Neoplasms, Experimental / chemically induced
  • Neoplasms, Experimental / immunology*
  • T-Lymphocytes, Regulatory / immunology*

Substances

  • Methylcholanthrene