Epigenetic Regulation of Cardiac Development and Disease through DNA Methylation

J Life Sci (Westlake Village). 2019 Sep;1(2):1-10.


Epigenetic control mechanisms play critical roles in organ development and tissue homeostasis. Increasing evidence suggests that cardiac lineage commitment and cardiovascular disease are tightly regulated by epigenetic mechanisms, controlling changes in DNA methylation, histone modifications, ATP-dependent chromatin remodeling, and expression levels for non-coding RNAs. This review summarizes our current understanding of epigenetic control mechanisms regulating cardiac development and disease, particularly focuses on the function of DNA methylation and demethylation through families of DNA methyltransferases and dioxygenases.

Keywords: DNA methylation; cardiac development; cardiovascular disease; epigenetics.