Clock-controlled rhythmic transcription: is the clock enough and how does it work?

Transcription. 2019 Aug-Oct;10(4-5):212-221. doi: 10.1080/21541264.2019.1673636. Epub 2019 Oct 9.


Circadian clocks regulate the rhythmic expression of thousands of genes underlying the daily oscillations of biological functions. Here, we discuss recent findings showing that circadian clock rhythmic transcriptional outputs rely on additional mechanisms than just clock gene DNA binding, which may ultimately contribute to the plasticity of circadian transcriptional programs.

Keywords: CLOCK:BMAL1; Circadian clock; chromatin interactions; enhancers; nucleosomes; rhythmic transcription; transcription factors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Circadian Clocks*
  • Gene Expression Regulation
  • Humans
  • Promoter Regions, Genetic
  • Transcription Factors / metabolism
  • Transcription, Genetic*


  • Transcription Factors

Grants and funding

This work was supported by startup funds from Texas A&M University.