Clock-controlled rhythmic transcription: is the clock enough and how does it work?

Joshua R Beytebiere; Ben J Greenwell; Aishwarya Sahasrabudhe; Jerome S Menet

doi:10.1080/21541264.2019.1673636

Clock-controlled rhythmic transcription: is the clock enough and how does it work?

Transcription. 2019 Aug-Oct;10(4-5):212-221. doi: 10.1080/21541264.2019.1673636. Epub 2019 Oct 9.

Authors

Joshua R Beytebiere¹, Ben J Greenwell^{1

2}, Aishwarya Sahasrabudhe¹, Jerome S Menet^{1

2}

Affiliations

¹ Department of Biology, Center for Biological Clock Research, Texas A&M University, TX, USA.
² Program of Genetics, Texas A&M University, College Station, TX, USA.

Abstract

Circadian clocks regulate the rhythmic expression of thousands of genes underlying the daily oscillations of biological functions. Here, we discuss recent findings showing that circadian clock rhythmic transcriptional outputs rely on additional mechanisms than just clock gene DNA binding, which may ultimately contribute to the plasticity of circadian transcriptional programs.

Keywords: CLOCK:BMAL1; Circadian clock; chromatin interactions; enhancers; nucleosomes; rhythmic transcription; transcription factors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Circadian Clocks*
Gene Expression Regulation
Humans
Promoter Regions, Genetic
Transcription Factors / metabolism
Transcription, Genetic*

Substances

Transcription Factors

Grants and funding

This work was supported by startup funds from Texas A&M University.