Mining the Proteome Associated with Rheumatic and Autoimmune Diseases

J Proteome Res. 2019 Dec 6;18(12):4231-4239. doi: 10.1021/acs.jproteome.9b00360. Epub 2019 Oct 23.


A steady increase in the incidence of osteoarthritis and other rheumatic diseases has been observed in recent decades, including autoimmune conditions such as rheumatoid arthritis, spondyloarthropathies, systemic lupus erythematosus, systemic sclerosis, and Sjögren's syndrome. Rheumatic and autoimmune diseases (RADs) are characterized by the inflammation of joints, muscles, or other connective tissues. In addition to often experiencing debilitating mobility and pain, RAD patients are also at a higher risk of suffering comorbidities such as cardiovascular or infectious events. Given the socioeconomic impact of RADs, broad research efforts have been dedicated to these diseases worldwide. In the present work, we applied literature mining platforms to identify "popular" proteins closely related to RADs. The platform is based on publicly available literature. The results not only will enable the systematic prioritization of candidates to perform targeted proteomics studies but also may lead to a greater insight into the key pathogenic processes of these disorders.

Keywords: Human Proteome Project; autoimmune diseases; bioinformatics; osteoarthritis; rheumatic diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arthritis, Rheumatoid / metabolism
  • Autoimmune Diseases / metabolism*
  • Data Mining
  • Humans
  • Osteoarthritis / metabolism
  • Proteins / metabolism*
  • Proteome*
  • Rheumatic Diseases / metabolism*


  • Proteins
  • Proteome