Influence of Inflammation in Uveitis on Confocal Scanning Laser Tomography and Optical Coherence Tomography Measurements

Ocul Immunol Inflamm. 2020 Jul 3;28(5):821-827. doi: 10.1080/09273948.2019.1625930. Epub 2019 Oct 10.


Purpose: To evaluate the influence of active inflammation in uveitis on confocal scanning laser tomography (CSLT) and optical coherence tomography (OCT) measurements.

Methods: Prospective enrollment of patients (64 eyes) with non-infectious uveitis. Retinal nerve fiber layer (RNFL), rim-area and -volume for CSLT and Bruch's-membrane-opening minimum-rim-width (BMO-MRW) and retinal nerve fiber layer thickness (RNFL-O) for OCT were recorded.

Results: No significant differences between eyes with active inflammation (31) vs no inflammation (33) were observed for all investigated CSLT parameters and BMO-MRW. The RNFL-O in OCT was significantly increased (1st p = .0439, 2nd p = .0327, 3rd p = .0313) while actively inflamed. CSLT did not show a significant difference between glaucomatous and non-glaucomatous eyes albeit all OCT derived parameters did.

Conclusion: CSLT measurements were not affected by inflammation but unreliable in glaucomatous eyes. RNFL-O was significantly influenced by inflammation while BMO-MRW was not. BMO-MRW seems to be the best approach in uveitic eyes.

Keywords: Confocal scanning laser tomography; glaucoma; inflammation; optical coherence tomography; uveitis.

MeSH terms

  • Adult
  • Bruch Membrane / diagnostic imaging
  • Female
  • Glaucoma, Open-Angle / diagnostic imaging
  • Glaucoma, Open-Angle / physiopathology*
  • Humans
  • Inflammation / diagnostic imaging
  • Inflammation / physiopathology*
  • Intraocular Pressure / physiology
  • Male
  • Microscopy, Confocal
  • Middle Aged
  • Nerve Fibers / pathology
  • Optic Disk / diagnostic imaging
  • Optic Nerve Diseases / diagnostic imaging
  • Optic Nerve Diseases / physiopathology*
  • Prospective Studies
  • Retinal Ganglion Cells / pathology
  • Tomography, Optical Coherence
  • Uveitis / diagnostic imaging
  • Uveitis / physiopathology*