[Reviews on natural monocyclic sesquiterpenoids and their bioactivities]

Zhongguo Zhong Yao Za Zhi. 2019 Sep;44(17):3672-3683. doi: 10.19540/j.cnki.cjcmm.20190415.201.
[Article in Chinese]


Sesquiterpenes are a class of terpenoids composed of three isoprene units( 15 carbons). Sesquiterpenoids possess a variety of different structures,including acyclic sesquiterpenes,monocyclic sesquiterpenoids,bicyclic sesquiterpenoids,tricyclic sesquiterpenoids,tetracyclic sesquiterpenoids and macrocyclic sesquiterpenoids. Among them,a large number of monocyclic sesquiterpenoids were isolated and display extensive bioactivities,such as cytotoxic,antioxidant,anti-inflammatory,antibacterial and other activities. In this review,we summarized the progress about the phytochemistry and biological activities of monocyclic sesquiterpenoids( a total of161 compounds) reported from 2014 to 2018( 5 years),including megastigmanes,monocyclofarnesol-type,bisabolane-type,germacrane-type,and other types of monocyclic sesquiterpenoids. Furthermore,several future research perspectives and development of sesquiterpenoids as potential therapeutic agents were discussed as well.

Keywords: anti-inflammatory activity; antioxidative; cytotoxicity; monocyclic sesquiterpenes; neuroprotective activity.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Inflammatory Agents / pharmacology
  • Antioxidants / pharmacology
  • Molecular Structure
  • Sesquiterpenes / pharmacology*


  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents
  • Antioxidants
  • Sesquiterpenes