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Meta-Analysis
, 13 (10), e0007808
eCollection

Differential Impact of Mass and Targeted Praziquantel Delivery on Schistosomiasis Control in School-Aged Children: A Systematic Review and Meta-Analysis

Affiliations
Meta-Analysis

Differential Impact of Mass and Targeted Praziquantel Delivery on Schistosomiasis Control in School-Aged Children: A Systematic Review and Meta-Analysis

Danielle M Cribb et al. PLoS Negl Trop Dis.

Abstract

Background: Schistosomiasis is a widespread public health concern in the poorest regions of the world. The principal control strategy is regular praziquantel administration to school-aged children in endemic areas. With calls for the elimination of schistosomiasis as a public health problem, expanding praziquantel delivery to all community members has been advocated. This systematic review and meta-analysis compares the impact of community-wide and child-targeted praziquantel distribution on schistosomiasis prevalence and intensity in school-aged children.

Methodology/principal findings: We searched MEDLINE, Embase and Web of Science to identify papers that reported schistosome prevalence before and after praziquantel administration, either to children only or to all community members. Extracted data included Schistosoma species, drug administration strategy, number of treatment rounds, follow-up interval and prevalence and intensity before and after treatment. We used inverse variance weighted generalised linear models to examine the impact of mass versus targeted drug administration on prevalence reduction, and weighted boxplots to examine the impact on infection intensity reduction. This study is registered with PROSPERO, number CRD42018095377. In total, 34 articles were eligible for systematic review and 28 for meta-analysis. Schistosoma mansoni was reported in 20 studies; Schistosoma haematobium in 19 studies, and Schistosoma japonicum in two studies. Results of generalised linear models showed no detectable difference between mass and targeted treatment strategies on prevalence reduction in school-aged children for S. mansoni (odds ratio 0.47, 95%CI 0.13-1.68, p = 0.227) and S. haematobium (0.41, 95%CI 0.06-3.03, p = 0.358). Box plots also showed no apparent differences in intensity reduction between the two treatment strategies.

Conclusions/significance: The results of this meta-analysis do not support the hypothesis that community-wide treatment is more effective than targeted treatment at reducing schistosomiasis infections in children. This may be due to the relatively small number of included studies, insufficient treatment coverage, persistent infection hotspots and unmeasured confounders. Further field-based studies comparing mass and targeted treatment are required.

Conflict of interest statement

The authors have declared no competing interests exist.

Figures

Fig 1
Fig 1. Process of selection of studies for inclusion in this synthesis.
Fig 2
Fig 2
Boxplots of infection intensity reduction for S. mansoni (A) and S. haematobium (B) for studies using mass and targeted strategies. Studies were weighted according to their sample size.

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References

    1. James SL, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet. 2018;392(10159):1789–1858. - PMC - PubMed
    1. WHO. Schistosomiasis and soiltransmitted helminthiases: numbers of people treated in 2017. Wkly Epidemiol Rec. 2018;93(50):681–692.
    1. Rollinson D, Knopp S, Levitz S, Stothard JR, Tchuem Tchuente LA, Garba A, et al. Time to set the agenda for schistosomiasis elimination. Acta Trop. 2013;128(2):423–440. 10.1016/j.actatropica.2012.04.013 - DOI - PubMed
    1. Colley DG, Bustinduy AL, Secor E, King CH. Human schistosomiasis. Lancet. 2014;383(9936):2253–2264. 10.1016/S0140-6736(13)61949-2 - DOI - PMC - PubMed
    1. WHO. Preventive chemotherapy in human helminthiasis: coordinated use of anthelminthic drugs in control interventions: a manual for health professionals and programme managers Crompton DWT, WHO, editors. Geneva: World Health Organization; 2006.

Grant support

The authors received no specific funding for this work
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