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. 2020 Jan;73(1):28-34.
doi: 10.1038/s41429-019-0246-0. Epub 2019 Oct 11.

Structure elucidation and biosynthetic locus of trinickiabactin from the plant pathogenic bacterium Trinickia caryophylli

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Structure elucidation and biosynthetic locus of trinickiabactin from the plant pathogenic bacterium Trinickia caryophylli

Junjing Jiao et al. J Antibiot (Tokyo). 2020 Jan.

Abstract

Within the framework of our effort to discover new bioactive metabolites from Gram-negative bacteria, trinickiabactin (1) was isolated from the plant pathogenic strain Trinickia caryophylli DSM 50341. Whole genome sequencing allowed the identification of its biosynthetic gene cluster. The structure of 1 bears a rare diazeniumdiolate ligand system and was elucidated by a combination of NMR- and MS-spectroscopic techniques and bioinformatics. Trinickiabactin was found to be antibacterial toward several Gram-negative bacteria (MIC values ranged from 3.5 to 34.0 µg ml-1).

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