Structure elucidation and biosynthetic locus of trinickiabactin from the plant pathogenic bacterium Trinickia caryophylli
- PMID: 31605027
- DOI: 10.1038/s41429-019-0246-0
Structure elucidation and biosynthetic locus of trinickiabactin from the plant pathogenic bacterium Trinickia caryophylli
Abstract
Within the framework of our effort to discover new bioactive metabolites from Gram-negative bacteria, trinickiabactin (1) was isolated from the plant pathogenic strain Trinickia caryophylli DSM 50341. Whole genome sequencing allowed the identification of its biosynthetic gene cluster. The structure of 1 bears a rare diazeniumdiolate ligand system and was elucidated by a combination of NMR- and MS-spectroscopic techniques and bioinformatics. Trinickiabactin was found to be antibacterial toward several Gram-negative bacteria (MIC values ranged from 3.5 to 34.0 µg ml-1).
References
-
- Yabuuchi E, Kosako Y, Oyaizu H, Yanu I, Hotta H, Hashimoto Y, et al. Proposal of Burkholderia gen. nov. and transfer of seven species of the genus Pseudomonas homology group II to the new genus, with the type species Burkholderia cepacia (Palleroni and Holmes 1981) comb. nov. Microbiol Immunol. 1992;36:1251–75. - DOI
-
- Eberl L, Vandamme P. Members of the genus Burkholderia: good and bad guys. F1000Research. 2016;5:1007. - DOI
-
- Kunakom S, Eustáquio AS. Burkholderia as a source of natural products. J Nat Prod. 2019;82:2018–37. - DOI
-
- Liu X, Cheng Y-Q. Genome-guided discovery of diverse natural products from Burkholderia sp. J Ind Microbiol Biotechnol. 2014;41:275–84. - DOI
-
- Esmaeel Q, Pupin M, Kieu NP, Chataigné G, Béchet M, Deravel J, et al. Burkholderia genome mining for nonribosomal peptide synthetases reveals a great potential for novel siderophores and lipopeptides synthesis. MicrobiologyOpen. 2016;5:512–26. - DOI
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases
