Alzheimer's disease (AD) is a progressive dementia caused by degeneration of the central nervous system with a high incidence in the elderly. Resveratrol is a natural compound contained in a wide range of plant species, including grapes. Recent studies have shown positive effects of resveratrol in animal models of AD; however, whether these results justify clinical trials is uncertain. Furthermore, there are multiple theories about the mechanism(s) by which resveratrol works and knowing how it works can suggest targets for future drug development. So far, systematic evaluation of both of these aspects is lacking. In this study, we selected 19 studies describing the efficacy of resveratrol in rodent AD models by electronic and manual retrieval. The method quality of the study were analyzed by the SYRCLE's risk of bias tool and the experimental data were retrieved and meta-analyzed using forest plot. Analysis of these studies demonstrates the consistent neuroprotective effects of resveratrol in AD models and offers insights into the possible pharmacological mechanisms. This information eliminates the bias of each study, providing supporting evidence for the implementation of clinical trials. However, the limits of studies were also noticed: low method quality, lack of sample size calculation and high risks of bias.
Keywords: Alzheimer’s disease; Animal AD models; Neuroprotective effects; Resveratrol.
Copyright © 2019 Elsevier Ltd. All rights reserved.
Quercetin in Animal Models of Alzheimer's Disease: A Systematic Review of Preclinical StudiesXW Zhang et al. Int J Mol Sci 21 (2). PMID 31941000. - ReviewAlzheimer's disease (AD) is the leading cause of dementia worldwide. It involves progressive impairment of cognitive function. A growing number of neuroprotective compoun …
Resveratrol, a Neuroprotective Supplement for Alzheimer's DiseaseF Li et al. Curr Pharm Des 18 (1), 27-33. PMID 22211686. - ReviewThe polyphenolic compound resveratrol (3,4',5-trihydroxystilbene) is a naturally occurring phytochemical which has been found in more than 70 plant species, including her …
Neuroprotective Effects of Berberine in Animal Models of Alzheimer's Disease: A Systematic Review of Pre-Clinical StudiesNN Yuan et al. BMC Complement Altern Med 19 (1), 109. PMID 31122236.AD is likely to be a complex disease driven by multiple factors. Yet, many therapeutic strategies based on lowering β-amyloid have failed in clinical trials. This suggest …
Resveratrol and Alzheimer's Disease: Mechanistic InsightsT Ahmed et al. Mol Neurobiol 54 (4), 2622-2635. PMID 26993301. - ReviewAlzheimer's disease (AD) is the leading cause of dementia in the elderly and is characterized by progressive cognitive and memory deficits. The pathological hallmarks of …
Effect of Resveratrol on In Vitro and In Vivo Models of Diabetic Retinophathy: A Systematic ReviewMD Toro et al. Int J Mol Sci 20 (14). PMID 31319465.A large number of preclinical studies suggest the involvement of resveratrol in the prevention and treatment of eye diseases induced by oxidative stress and inflammation. …