Reproductive and hormonal considerations in women at increased risk for hereditary gynecologic cancers: Society of Gynecologic Oncology and American Society for Reproductive Medicine Evidence-Based Review

Fertil Steril. 2019 Dec;112(6):1034-1042. doi: 10.1016/j.fertnstert.2019.07.1349. Epub 2019 Oct 9.


Providers who care for women at risk for hereditary gynecologic cancers must consider the impact of these conditions on reproductive and hormonal health. This document reviews potential options for cancer prevention, family building, genetic testing and management of surgical menopause in this patient population.

Keywords: Genetic counseling; endometrial cancer; menopause and hormone replacement therapy; ovarian cancer; quality of life issues.

Publication types

  • Practice Guideline
  • Review

MeSH terms

  • Consensus
  • Evidence-Based Medicine
  • Female
  • Fertility Preservation* / adverse effects
  • Fertility*
  • Genetic Predisposition to Disease
  • Genital Neoplasms, Female / genetics*
  • Genital Neoplasms, Female / prevention & control*
  • Humans
  • Infertility, Female / diagnosis
  • Infertility, Female / physiopathology
  • Infertility, Female / therapy*
  • Pregnancy
  • Reproductive Health*
  • Reproductive Medicine
  • Reproductive Techniques, Assisted* / adverse effects
  • Risk Assessment
  • Risk Factors
  • Treatment Outcome