Perinatal exposure to bisphenol A (BPA) impairs neuroendocrine mechanisms regulating food intake and kisspetin system in adult male rats. Evidences of metabolic disruptor hypothesis

Mol Cell Endocrinol. 2020 Jan 1;499:110614. doi: 10.1016/j.mce.2019.110614. Epub 2019 Oct 10.

Abstract

Bisphenol A (BPA) is a compound used in the polymerization of plastic polycarbonates. It is an endocrine disruptor and it has been postulated to be an obesogen. Our objective was to determine the influence of perinatal exposure to BPA on body weight, hormone levels, metabolic parameters and hypothalamic signals that regulate food intake and kisspeptin system in adult male rats. Male rats were exposed to 50 μg/kg/day of BPA or vehicle from day 9 of gestation to weaning in the drinking water. Since weaning, they were fed with control or high fat diet for 20 weeks. Perinatal exposure to BPA impaired glucose homeostasis, induced obesity and increased food intake in adult male rats altering hypothalamic signals, partially mimicking and/or producing an exacerbation of the effects of feeding fat diet. We also observed an increase in kisspeptin expression by BPA exposure. Evidences shown in this work support the metabolic disruptor hypothesis for BPA.

Keywords: Bpa; Diabetes; Food intake; Kisspeptin; Neuropeptides; Obesogen.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzhydryl Compounds / adverse effects*
  • Body Weight / drug effects
  • Diet, High-Fat / adverse effects
  • Disease Models, Animal
  • Endocrine Disruptors / adverse effects*
  • Female
  • Glucose / metabolism
  • Kisspeptins / metabolism*
  • Male
  • Obesity / chemically induced*
  • Obesity / metabolism
  • Phenols / adverse effects*
  • Pregnancy
  • Prenatal Exposure Delayed Effects / chemically induced
  • Prenatal Exposure Delayed Effects / metabolism*
  • Rats

Substances

  • Benzhydryl Compounds
  • Endocrine Disruptors
  • Kisspeptins
  • Phenols
  • Glucose
  • bisphenol A