Amoxicillin-clavulanate-induced Granulomatous Hepatitis: Case Report and Review of the Literature

Avin Aggarwal; Neha Jaswal; Richa Jain; Hussien Elsiesy

doi:10.14218/JCTH.2019.00027

Amoxicillin-clavulanate-induced Granulomatous Hepatitis: Case Report and Review of the Literature

J Clin Transl Hepatol. 2019 Sep 28;7(3):280-283. doi: 10.14218/JCTH.2019.00027. Epub 2019 Jul 26.

Authors

Avin Aggarwal¹, Neha Jaswal¹, Richa Jain², Hussien Elsiesy³

Affiliations

¹ Department of Medicine, University of Arizona, Tucson, AZ, USA.
² Department of Pathology, University of Arizona, Tucson, AZ, USA.
³ Liver consultants of Texas, Baylor All Saints Medical Center, Fort Worth, TX, USA.

Abstract

Amoxicillin-clavulanate (AC) is a common cause of drug-induced liver injury, either cholestatic or mixed with hepatitis pattern. Rarely, AC causes granulomatous hepatitis. We report a new case of AC-induced granulomatous hepatitis documented by liver biopsy, with complete resolution of any histological sequelae on a follow-up liver biopsy after AC was withdrawn.

Keywords: Amoxicillin; Clavulanate; Drug-induced liver injury; Granulomatous hepatitis; Liver biopsy.

Publication types

Review