Structural neuroimaging in mild traumatic brain injury: A chronic effects of neurotrauma consortium study

Int J Methods Psychiatr Res. 2019 Sep;28(3):e1781. doi: 10.1002/mpr.1781. Epub 2019 May 23.


Objectives: The chronic effects of neurotrauma consortium (CENC) observational study is a multisite investigation designed to examine the long-term longitudinal effects of mild traumatic brain injury (mTBI). All participants in this initial CENC cohort had a history of deployment in Operation Enduring Freedom (Afghanistan), Operation Iraqi Freedom (Iraq), and/or their follow-on conflicts (Operation Freedom's Sentinel). All participants undergo extensive medical, neuropsychological, and neuroimaging assessments and either meet criteria for any lifetime mTBI or not. These assessments are integrated into six CENC core studies-Biorepository, Biostatistics, Data and Study Management, Neuroimaging, and Neuropathology.

Methods: The current study outlines the quantitative neuroimaging methods managed by the Neuroimaging Core using FreeSurfer automated software for image quantification.

Results: At this writing, 319 participants from the CENC observational study have completed all baseline assessments including the imaging protocol and tertiary data quality assurance procedures.

Conclusions/discussion: The preliminary findings of this initial cohort are reported to describe how the Neuroimaging Core manages neuroimaging quantification for CENC studies.

Keywords: automated image analysis; cognitive assessment; mild traumatic brain injury; neuroimaging quantification; veterans.

Publication types

  • Multicenter Study
  • Observational Study
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Brain / diagnostic imaging*
  • Brain Concussion / diagnostic imaging*
  • Chronic Disease
  • Cohort Studies
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neuroimaging*