GM-CSF in inflammation

J Exp Med. 2020 Jan 6;217(1):e20190945. doi: 10.1084/jem.20190945.


Granulocyte-macrophage colony-stimulating factor (GM-CSF) has many more functions than its original in vitro identification as an inducer of granulocyte and macrophage development from progenitor cells. Key features of GM-CSF biology need to be defined better, such as the responding and producing cell types, its links with other mediators, its prosurvival versus activation/differentiation functions, and when it is relevant in pathology. Significant preclinical data have emerged from GM-CSF deletion/depletion approaches indicating that GM-CSF is a potential target in many inflammatory/autoimmune conditions. Clinical trials targeting GM-CSF or its receptor have shown encouraging efficacy and safety profiles, particularly in rheumatoid arthritis. This review provides an update on the above topics and current issues/questions surrounding GM-CSF biology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Arthritis, Rheumatoid / immunology
  • Cell Differentiation / immunology
  • Granulocyte-Macrophage Colony-Stimulating Factor / immunology*
  • Granulocytes / immunology
  • Humans
  • Inflammation / immunology*
  • Macrophages / immunology


  • Granulocyte-Macrophage Colony-Stimulating Factor