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. 2019 Oct 15;322(15):1515-1517.
doi: 10.1001/jama.2019.12925.

Association of Maternal Gastric Bypass Surgery With Offspring Birth Defects

Martin Neovius  1 , Björn Pasternak  1 , Ingmar Näslund  2 , Jonas Söderling  1 , Kari Johansson  1 , Olof Stephansson  1
Affiliations

Association of Maternal Gastric Bypass Surgery With Offspring Birth Defects

Martin Neovius et al. JAMA. .

Abstract

This cohort study uses Swedish Medical Birth Register data to investigate risk of birth defects in infants born to women who had Roux-en-Y bariatric surgery between 2007 and 2014.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Neovius reported receipt of advisory board fees from Itrim and Ethicon Johnson & Johnson. Dr Pasternak reported receipt of an unrestricted research grant from the Novo Nordisk Foundation for a diabetes project not related to the present work. Dr Näslund reported receipt of consultancy and lecture fees from Baricol Bariatrics AB Sweden and Ethicon Johnson & Johnson and lecture fees from AstraZeneca A/S Denmark. Dr Söderling reported receipt of consultancy fees from Itrim. No other disclosures were reported.

Figures

Figure.
Figure.. Major Birth Defects in Infants Born to Women With Gastric Bypass Surgery and Matched Controls
Matched controls: exact matching by maternal presurgery body mass index and diabetes (early-pregnancy body mass index and preconception diabetes used for controls), history of major birth defects in previous pregnancies, delivery year, and a propensity score based on maternal age, alcohol and substance use, smoking, parity, psychiatric drug use, and number of prescription drugs. For first birth after gastric bypass surgery, restriction was performed to avoid clustering effects (13% of mothers had >1 birth after surgery). Weights from coarsened exact matching were used to account for different sizes of matching strata.
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