Tuning the regulator: Phosphorylation of KCC2 at two specific sites is critical for neurodevelopment

Sci Signal. 2019 Oct 15;12(603):eaay8960. doi: 10.1126/scisignal.aay8960.


The K+/Cl- cotransporter KCC2 is a molecular switch between excitatory and inhibitory effects of GABAergic inputs into neurons. In a pair of exciting studies, Watanabe et al. and Pisella et al. elucidate the role of KCC2 dephosphorylation in this process and reveal its consequences for neurodevelopment and nervous system pathology.

Publication types

  • Review
  • Comment

MeSH terms

  • Neurons*
  • Phosphorylation
  • Symporters*


  • Symporters