Oscillating circuitries in the sleeping brain

Nat Rev Neurosci. 2019 Dec;20(12):746-762. doi: 10.1038/s41583-019-0223-4. Epub 2019 Oct 15.


Brain activity during sleep is characterized by circuit-specific oscillations, including slow waves, spindles and theta waves, which are nested in thalamocortical or hippocampal networks. A major challenge is to determine the relationships between these oscillatory activities and the identified networks of sleep-promoting and wake-promoting neurons distributed throughout the brain. Improved understanding of the neurobiological mechanisms that orchestrate sleep-related oscillatory activities, both in time and space, is expected to generate further insight into the delineation of sleep states and their functions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / physiology*
  • Electroencephalography* / methods
  • Humans
  • Nerve Net / physiology*
  • Sleep / physiology
  • Sleep Stages / physiology*
  • Wakefulness / physiology*