Loading AKBA on surface of silver nanoparticles to improve their sedative-hypnotic and anti-inflammatory efficacies

Nanomedicine (Lond). 2019 Nov;14(21):2783-2798. doi: 10.2217/nnm-2019-0211. Epub 2019 Oct 16.


Aim: Acetyl-11-keto-β-boswellic acid (AKBA) is a potent anti-inflammatory compound limited by its low water solubility and bioavailability. To load AKBA on silver nanoparticles (AgNPs) to improve bioavailability and water solubility of the compound. Materials & methods: AKBA-AgNPs were chemically synthesized and characterized by UV-Vis spectrophotometry, Fourier transform infrared spectroscopy, scanning electron microscopy and transmission electron microscopy. AKBA and AKBA-Ag were studied for their sedative-hypnotic and anti-inflammatory efficacies. Results: Pretreatment with AKBA or AKBA-Ag caused significant dose-dependent sedative-hypnotic effects at 5 and 10 mg/kg intraperitoneal. The effects of AKBA-loaded AgNPs caused pronounced changes in mice compared with those of AKBA, and the AKBA-AgNPs demonstrated anti-inflammatory effects that were superior to those of AKBA. Conclusion: The loading of AKBA on nanoparticles improved its pharmacokinetic effects, and capacity for drug delivery.

Keywords: Boswellia; AKBA; AKBA-Ag; FTIR; SEM; TEM; acetyl-11-keto-β-boswellic acid; anti-inflammatory effects; heat effect; nanoparticles; optimization; sedative-hypnotic like effects.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / pharmacokinetics
  • Boswellia / chemistry
  • Drug Carriers / chemistry*
  • Drug Liberation
  • Drug Stability
  • Hypnotics and Sedatives / administration & dosage
  • Hypnotics and Sedatives / chemistry*
  • Hypnotics and Sedatives / pharmacokinetics
  • Male
  • Metal Nanoparticles / chemistry*
  • Mice
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacokinetics
  • Silver / chemistry*
  • Sleep / drug effects
  • Treatment Outcome
  • Triterpenes / administration & dosage
  • Triterpenes / chemistry*
  • Triterpenes / pharmacokinetics


  • Anti-Inflammatory Agents
  • Drug Carriers
  • Hypnotics and Sedatives
  • Plant Extracts
  • Triterpenes
  • acetyl-11-ketoboswellic acid
  • Silver