The Neuropeptide CGRP Induces Bipolar Syndrome in Group 2 Innate Lymphoid Cells

Yasutaka Motomura; Tetsuro Kobayashi; Kazuyo Moro

doi:10.1016/j.immuni.2019.09.015

The Neuropeptide CGRP Induces Bipolar Syndrome in Group 2 Innate Lymphoid Cells

Immunity. 2019 Oct 15;51(4):598-600. doi: 10.1016/j.immuni.2019.09.015.

Authors

Yasutaka Motomura¹, Tetsuro Kobayashi², Kazuyo Moro³

Affiliations

¹ Laboratory for Innate Immune Systems, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka Suita-shi, Osaka 565-0871, Japan.
² Laboratory for Innate Immune Systems, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
³ Laboratory for Innate Immune Systems, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka Suita-shi, Osaka 565-0871, Japan; Laboratory for Innate Immune Systems, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan; Laboratory for Innate Immune Systems, Immunology Frontier Research Center (iFReC), Osaka University, 3-1, Yamadaoka Suita-shi, Osaka 565-0871, Japan. Electronic address: moro@ilc.med.osaka-u.ac.jp.

PMID: 31618650
DOI: 10.1016/j.immuni.2019.09.015

Abstract

In this issue of Immunity, Nagashima et al., Wallrapp et al., and Xu et al. demonstrate that the neuropeptide calcitonin gene-related peptide (CGRP) fine tunes type 2 innate immune response via suppressing group 2 innate lymphoid cells (ILC2s).

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MeSH terms

Bipolar Disorder*
Calcitonin
Calcitonin Gene-Related Peptide*
Humans
Immunity, Innate
Inflammation
Lymphocytes

Substances

Calcitonin
Calcitonin Gene-Related Peptide