rs73185306 C/T Is Not a Predisposing Risk Factor for Inherited Chromosomally Integrated Human Herpesvirus 6A/B

J Infect Dis. 2020 Mar 2;221(6):878-881. doi: 10.1093/infdis/jiz527.

Abstract

Approximately 1% of people worldwide carry a copy of the human herpesvirus 6A or 6B (HHV-6A/B) in every cell of their body. This condition is referred to as inherited chromosomally integrated HHV-6A/B (iciHHV-6A/B). The mechanisms leading to iciHHV-6A/B chromosomal integration are yet to be identified. A recent report suggested that the rs73185306 C/T single-nucleotide polymorphism (SNP) represents a favorable predisposing factor leading to HHV-6A/B integration. After genotype analysis of an independent cohort (N = 11 967), we report no association between the rs73185306 C/T SNP and HHV-6A/B chromosomal integration (odds ratio, 0.90 [95% confidence interval, .54-1.51]; P = .69).

Keywords: HHV-6; HHV-6A/B; herpesviruses; iciHHV-6; integration; rs73185306 C/T SNP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Cohort Studies
  • DNA, Viral / genetics
  • Genetic Predisposition to Disease*
  • Herpesvirus 6, Human / genetics*
  • Humans
  • Point Mutation*
  • Reproducibility of Results
  • Risk Factors
  • Virus Integration

Substances

  • DNA, Viral

Grant support