Fragile sites and neuroblastoma: fragile site at 1p13.1 and other points on lymphocyte chromosomes from patients and family members

Cancer Genet Cytogenet. 1988 Mar;31(1):83-94. doi: 10.1016/0165-4608(88)90015-5.


Fragile sites on lymphocyte chromosomes of 20 patients with neuroblastoma of different clinical stages and histologic differentiation were studied. A hitherto unknown break in the band p13.1 of chromosome #1 was found in a frequency of 3%-15% in nine cases. The same phenomenon was observed in three members of a neuroblastoma family. In another instance, this fragile site was also seen in the mother of a patient. Fragile sites were expressed when cells were cultured in folate-deprived medium and could be slightly enhanced in frequency by aphidicolin. Additional aphidicolin induced possible fragile sites hitherto unknown or not yet accepted by the HGM 8 were detected.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child, Preschool
  • Chromosome Banding
  • Chromosome Fragile Sites
  • Chromosome Fragility*
  • Chromosomes, Human, Pair 1*
  • Female
  • Genetic Markers
  • Humans
  • Infant
  • Karyotyping
  • Lymphocytes / ultrastructure
  • Male
  • Neuroblastoma / genetics*
  • Pedigree


  • Genetic Markers