Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase)

FEBS Lett. 1988 Feb 29;229(1):206-10. doi: 10.1016/0014-5793(88)80828-7.


We have isolated a cDNA clone encoding human enkephalinase (neutral endopeptidase, EC in a lambda gt10 library from human placenta, and present the complete 742 amino acid sequence of human enkephalinase. The human enzyme displays a high homology with rat and rabbit enkephalinase. Like the rat and rabbit enzyme, human enkephalinase contains a single N-terminal transmembrane region and is likely to be inserted through cell membranes with the majority of protein, including its carboxy-terminus, located extracellularly.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Membrane / enzymology
  • Cloning, Molecular*
  • DNA / analysis
  • Humans
  • Metalloendopeptidases / analysis*
  • Metalloendopeptidases / genetics
  • Molecular Sequence Data
  • Neprilysin
  • Rabbits
  • Rats


  • DNA
  • Metalloendopeptidases
  • Neprilysin

Associated data

  • GENBANK/X07166