Low vitamin B12 level and vitamin D level adversely affect on cochlear health in women

Int J Vitam Nutr Res. 2020 Jun;90(3-4):333-338. doi: 10.1024/0300-9831/a000616. Epub 2019 Oct 18.


The aim of this study is to examine the association between low serum vitamin B12 levels and low serum vitamin D levels and cochlear health in women. A prospective case-control study was carried out in the Department of Otolaryngology, Malatya Training and Research Hospital between 2017-2018. Thirty (30) patients with vitamin B12 deficiency (a mean age of 32.5 ± 1.7 years(y) women); 30 patients with vitamin D deficiency (a mean age of 32.3 ± 1.58 y women) and 30 controls (a mean age of 27.8 ± 1.48 y women) were recruited. The study participants have no evidence of symptomatic hearing loss. Transiently evoked otoacoustic emissions (TEOAEs) and distortion product otoacoustic emissions (DPOAEs) of the study participants were recorded. A comparative analysis of the parameters revealed that results at TEOAE 1,2,3,4 kHz (p = 0.013, p = 0.002, p = 0.001, p = 0.001, respectively) and at DPOAE 1, 2, 6 kHz (p < 0.001, p < 0.001, p = 0.002, respectively) were somewhat lower in patients with vitamin B12 deficient group when compared with the controls. Moreover, TEOAE 3,4 kHz (p = 0.005, p = 0.013 respectively) and DPOAE 1,2,6 kHz (p = 0.005, p = 0.01, p = 0.031, respectively) were lower in the vitamin D deficiency group compared with the controls. There was a significant association between both vitamin B12 deficiency and vitamin D deficiency and cochlear health. Patients with vitamin B12 and vitamin D deficiency should be evaluated for cochlear function.

Keywords: Cochlear health; otoacoustic emission; vitamin B12; vitamin D; women.

MeSH terms

  • Adult
  • Case-Control Studies
  • Cochlea*
  • Female
  • Humans
  • Otoacoustic Emissions, Spontaneous*
  • Prospective Studies
  • Vitamin B 12 / chemistry
  • Vitamin B 12 / metabolism
  • Vitamin D / chemistry
  • Vitamin D / metabolism


  • Vitamin D
  • Vitamin B 12