Microglial Self-Recognition STINGs in A-T Neurodegeneration

Austin Ferro; Carrie Sheeler; Marija Cvetanovic

doi:10.1016/j.tins.2019.09.005

Microglial Self-Recognition STINGs in A-T Neurodegeneration

Trends Neurosci. 2019 Nov;42(11):753-755. doi: 10.1016/j.tins.2019.09.005. Epub 2019 Oct 14.

Authors

Austin Ferro¹, Carrie Sheeler¹, Marija Cvetanovic²

Affiliations

¹ Department of Neuroscience, University of Minnesota, 2101 6th Street South East, Minneapolis, MN 55455, USA.
² Department of Neuroscience, University of Minnesota, 2101 6th Street South East, Minneapolis, MN 55455, USA; Institute for Translational Neuroscience, University of Minnesota, 2101 6th Street South East, Minneapolis, MN 55455, USA. Electronic address: mcvetano@umn.edu.

Abstract

Microglial inflammation is often seen as a secondary event in neurodegeneration. A recent study by Song et al. demonstrates that loss of ataxia telangiectasia mutated (ATM) activates microglia through the cytosolic DNA sensor STING. This highlights the ability of microglia to recognize and respond to self-DNA, with potentially neurotoxic consequences.

Keywords: ATM; NF-κB; ataxia telangiectasia; microglia.

Publication types

Comment

MeSH terms

Ataxia Telangiectasia Mutated Proteins
Ataxia Telangiectasia*
DNA
Humans
Inflammation
Microglia

Substances

DNA
ATM protein, human
Ataxia Telangiectasia Mutated Proteins

Abstract

Publication types

MeSH terms

Substances

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