Dynamic Histone H3 Incorporation Fuels Metastatic Progression

Trends Mol Med. 2019 Nov;25(11):933-935. doi: 10.1016/j.molmed.2019.09.003. Epub 2019 Oct 14.


Treating metastatic cancers is an ongoing challenge in oncology. A recent paper by Gomes and colleagues proposes histone H3 variant dynamics as major regulator of cell fate transition during metastasis and suggests histone chaperones as therapeutic targets for invasive carcinoma.

Keywords: CAF-1; chromatin reprogramming; histone H3 dynamics; metastasis.

Publication types

  • Review

MeSH terms

  • Chromatin / metabolism
  • Histone Chaperones / metabolism*
  • Histones / metabolism*
  • Humans
  • Neoplasm Metastasis / pathology*
  • Neoplasms / pathology


  • Chromatin
  • Histone Chaperones
  • Histones