A Novel Association of Martorell Ulcer With Liddle Syndrome

Adv Skin Wound Care. 2019 Nov;32(11):1-2. doi: 10.1097/01.ASW.0000582616.30031.19.


Pseudohyperaldosteronism, or Liddle syndrome, is a rare, autosomal dominant condition characterized by early-onset hypertension, often associated with hypokalemia and metabolic alkalosis. Martorell hypertensive ischemic leg ulcer is a rare, underdiagnosed ulcer characterized by subcutaneous arteriolosclerosis, classically appearing over the dorsolateral lower extremity or Achilles tendon in patients with hypertension and diabetes. It presents an important diagnostic challenge because it can appear grossly similar to other entities such as pyoderma gangrenosum or venous stasis ulcers, but requires surgical intervention. This article presents a case study of surgical management of a Martorell ulcer in a 69-year-old woman with Liddle syndrome. To the authors' knowledge, this is the first case reported in the literature of this rare ulcer occurring secondary to this rare cause of hypertension.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Achilles Tendon / pathology*
  • Aged
  • Anti-Infective Agents, Local / pharmacology
  • Bandages, Hydrocolloid
  • Combined Modality Therapy
  • Debridement / methods
  • Female
  • Follow-Up Studies
  • Humans
  • Leg Ulcer / complications*
  • Leg Ulcer / diagnosis
  • Leg Ulcer / therapy*
  • Liddle Syndrome / complications*
  • Liddle Syndrome / diagnosis
  • Negative-Pressure Wound Therapy / methods*
  • Risk Assessment
  • Severity of Illness Index
  • Time Factors
  • Wound Healing / physiology*


  • Anti-Infective Agents, Local