Membrane-Active Rhamnolipids Overcome Aminoglycoside Resistance

Venkateswarlu Yarlagadda; Gerard D Wright

doi:10.1016/j.chembiol.2019.09.015

Membrane-Active Rhamnolipids Overcome Aminoglycoside Resistance

Cell Chem Biol. 2019 Oct 17;26(10):1333-1334. doi: 10.1016/j.chembiol.2019.09.015.

Authors

Venkateswarlu Yarlagadda¹, Gerard D Wright²

Affiliations

¹ David Braley Centre for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada.
² David Braley Centre for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada. Electronic address: wrightge@mcmaster.ca.

PMID: 31626780
DOI: 10.1016/j.chembiol.2019.09.015

Abstract

In this issue of Cell Chemical Biology, Radlinski et al. (2019) identify Pseudomonas-derived rhamnolipids that potentiate aminoglycoside antibiotics in the eradication of antibiotic-tolerant bacterial phenotypes. Microbial physiological and mechanistic studies indicate that rhamnolipids permeabilize S. aureus membrane and drive the uptake of aminoglycosides that is independent of proton-motive force.

Publication types

Comment

MeSH terms

Aminoglycosides
Anti-Bacterial Agents*
Glycolipids
Microbial Sensitivity Tests
Pseudomonas aeruginosa
Staphylococcus aureus*

Substances

Aminoglycosides
Anti-Bacterial Agents
Glycolipids
rhamnolipid