Multiscale Hill-type modeling of the mechanical muscle behavior driven by the neural drive in isometric conditions

Abstract

In this study, we present a new model describing the mechanical behavior of the skeletal muscle during isometric contraction. This model is based on a former Hill-inspired model detailing the electromechanical behavior of the muscle based on the Huxley formulation. However, in this new multiscale model the muscle is represented at the Motor Unit (MU) scale. The proposed model is driven by a physiological input describing the firing moments of the activated MUs. Definition of both voluntary and evoked MU recruitment schemes are described, enabling the study of both contractions in isometric conditions. During this type of contraction, there is no movement of the joints and the tendon-muscle complex remains at the same length. Moreover, some well-established macroscopic relationships such as force-length or force-velocity properties are considered. A comparison with a twitch model using the same input definition is provided with both recruitment schemes exhibiting limitations of twitch type models. Finally, the proposed model is validated with a comparison between simulated and recorded force profiles following eight electrical stimulations pulses in isometric conditions. The simulated muscle force was generated to mimic the one recorded from the quadriceps of a patient implanted with a functional electrical stimulation neuroprosthesis. This validation demonstrates the ability of the proposed model to reproduce realistically the skeletal muscle contractions and to take into account subject-specific parameters.

Keywords: Isometric contraction; Motor unit; Muscle multiscale mechanical model; Recruitment scheme.