Chromosomes in Ewing's sarcoma. II. Nonrandom additional changes, trisomy 8 and der(16)t(1;16)

Cancer Genet Cytogenet. 1988 Jun;32(2):239-45. doi: 10.1016/0165-4608(88)90286-5.


Chromosomal data from 82 informative, unrelated Ewing's sarcoma (ES) specimens (including 20 personal specimens) were reviewed for secondary changes additional to the t(11;22)(q24;q12). Additional numerical and/or structural changes were found in 75 specimens. Trisomy 8 was observed consistently in half of the 43 cases selected for analysis of numerical changes. A nonrandom der(16) was observed as a result of an unbalanced t(1;16) in 18% of the 82 analyzed for structural changes. Consistent involvement of chromosome #16 in rearrangements with chromosome #1 may be an additional chromosome change specifically associated with ES.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bone Neoplasms / genetics*
  • Chromosome Banding
  • Chromosomes, Human, Pair 1
  • Chromosomes, Human, Pair 16
  • Chromosomes, Human, Pair 8*
  • Genetic Markers
  • Humans
  • Karyotyping
  • Sarcoma, Ewing / genetics*
  • Translocation, Genetic*
  • Trisomy*


  • Genetic Markers