Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Mar;104:103524.
doi: 10.1016/j.dci.2019.103524. Epub 2019 Oct 18.

Spatial and Temporal Transcriptomic Analyses Reveal Locust Initiation of Immune Responses to Metarhizium Acridum at the Pre-Penetration Stage

Affiliations

Spatial and Temporal Transcriptomic Analyses Reveal Locust Initiation of Immune Responses to Metarhizium Acridum at the Pre-Penetration Stage

Wei Zhang et al. Dev Comp Immunol. .

Abstract

Insect hemocyte and fat body tissues play critical functional roles in insect immunity. Little, however, is known concerning the dynamic responses of these tissues to fungal infection. Here, we report on a time course of locust hemocyte and fat body transcriptomic responses to infection by the acridid specific fungal pathogen, Metarhizium acridum. Fat body responses were more pronounced at all infection stages as compared to hemocytes. Immune and other related genes were induced far earlier than previously considered including at pre-penetration stages. Differential expression in hemocyte and fat body tissues persisted throughout the course of infection up until host death. Our data indicate selective pressure on the host to recognize the infection as early as possible in order to limit its spread. Overall, fat body and hemocyte tissues launch a robust multi-tiered response to combat the fungal pathogen, with our data providing potential host targets for exploitation in pest control.

Keywords: Fat body; Hemocytes; Infection time course; Locust; Metarhizium; Transcriptomics.

Similar articles

See all similar articles

LinkOut - more resources

Feedback