Effect of sodium lauryl sulfate on the deposition of alkali-soluble fluoride on enamel in vitro

Caries Res. 1988;22(3):139-44. doi: 10.1159/000261094.


There are indications that sodium lauryl sulfate may reduce the cariostatic effect of fluoride when present together with sodium monofluorophosphate during topical application. The aim of the present study was to examine the in vitro deposition of alkali soluble fluoride on enamel during topical application with sodium fluoride in combination with sodium lauryl sulfate. It was found that increasing amounts of lauryl sulfate decreased the amount of alkali soluble fluoride deposited on the enamel. The amount of fluoride deposited from toothpaste supernatants was less than that from aqueous solutions of NaF with the same concentration of fluoride. Enamel pieces, pretreated with sodium lauryl sulfate showed a reduced deposition of alkali-soluble fluoride after incubation in a fluoride solution. It was also observed that the presence of lauryl sulfate increased the solubility of CaF2 in water.

MeSH terms

  • Administration, Topical
  • Alkalies
  • Calcium Fluoride / metabolism
  • Dental Enamel / metabolism*
  • Dental Enamel / ultrastructure
  • Dentifrices
  • Fluorides / metabolism*
  • Humans
  • Microscopy, Electron, Scanning
  • Sodium Dodecyl Sulfate / administration & dosage
  • Sodium Dodecyl Sulfate / pharmacology*
  • Sodium Fluoride / administration & dosage
  • Solubility


  • Alkalies
  • Dentifrices
  • Sodium Dodecyl Sulfate
  • Sodium Fluoride
  • Calcium Fluoride
  • Fluorides