A novel sensing material of cobalt oxide-bismuth phosphate (Co₃O₄-BiPO₄) was prepared by the hydrothermal method. Thus prepared sensing material was characterized by X-ray diffraction analysis (XRD) and transmission electron microscopy (TEM). The sensor was used for the determination of epinephrine by using modified Co₃O₄-BiPO₄ on glassy carbon electrode (GCE). The cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods showed a wide linear response to a concentration range, from 1.71 to 55.00 μM, and the epinephrine detection limit for this sensing system was found to be 1.334 μM. The Co₃O₄-BiPO₄ electrode has very high selectivity towards the detection of epinephrine supported by an interference test. The epinephrine sensor seems very advantageous for future clinical health and medical sectors.