Systems biology perspective for studying the gut microbiota in human physiology and liver diseases

EBioMedicine. 2019 Nov:49:364-373. doi: 10.1016/j.ebiom.2019.09.057. Epub 2019 Oct 18.

Abstract

The advancement in high-throughput sequencing technologies and systems biology approaches have revolutionized our understanding of biological systems and opened a new path to investigate unacknowledged biological phenomena. In parallel, the field of human microbiome research has greatly evolved and the relative contribution of the gut microbiome to health and disease have been systematically explored. This review provides an overview of the network-based and translational systems biology-based studies focusing on the function and composition of gut microbiota. We also discussed the association between the gut microbiome and the overall human physiology, as well as hepatic diseases and other metabolic disorders.

Keywords: Biomarker; Gut microbiome; Host-microbiome interactions; Liver diseases; Meta-omics; Metabolic models; Personalized medicine; Systems biology.

Publication types

  • Review

MeSH terms

  • Gastrointestinal Microbiome*
  • Humans
  • Liver Diseases / microbiology*
  • Liver Diseases / physiopathology*
  • Metabolism
  • Microbiota*
  • Pharmaceutical Preparations / metabolism
  • Systems Biology*

Substances

  • Pharmaceutical Preparations