Outcomes of neonates with listeriosis supported with extracorporeal membrane oxygenation from 1991 to 2017

J Perinatol. 2020 Jan;40(1):105-111. doi: 10.1038/s41372-019-0534-3. Epub 2019 Oct 21.

Abstract

Background: Listeriosis may cause severe disease in fetuses and neonates. The outcomes of critically ill neonates with early-onset listeriosis requiring extracorporeal membrane oxygenation (ECMO) from 1975 to 1991 have been reported.

Objective: To update the characteristics and outcomes of neonates with listeriosis supported by ECMO.

Study design: Retrospective study of neonates with culture-proven listeriosis reported to the Extracorporeal Life Support Organization Registry between 1991 and 2017. Comparisons were made between this cohort and the case series from 1975-1991.

Results: Twenty-two neonates had culture-proven Listeria monocytogenes infection and required ECMO support. Eight-six percent survived to discharge, compared with 67% in the previous cohort (p = 0.2). The median ECMO duration was 131 h, compared with 209 h in the previous cohort (p = 0.1). Nonsurvivors had a significantly lower pre-ECMO pH (6.91 vs 7.31, p = 0.0006).

Conclusion: The survival of neonates with listeriosis supported with ECMO is high, supporting the use of ECMO as rescue therapy for this condition.

MeSH terms

  • Comorbidity
  • Extracorporeal Membrane Oxygenation* / adverse effects
  • Female
  • Humans
  • Infant, Newborn
  • Infant, Newborn, Diseases / epidemiology
  • Listeriosis / complications
  • Listeriosis / mortality
  • Listeriosis / therapy*
  • Male
  • Retrospective Studies
  • Survival Rate